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Keith Cheng



  • Higher Ed: Science 


B.A., Harvard University, 1976
M.D., New York University School of Medicine, 1980
Ph.D., University of Washington and Fred Hutchinson Cancer Research Center, 1987
Residency: Brigham & Women's Hospital, 1980-81; University of Washington, 1981-82, 1986-87
Graduate School: University of Washington and Fred Hutchinson Cancer Research Center, 1982-86
Postdoc: University of Washington, 1987-1992
Current Positions: Professor of Pathology, Director of Expeirmental Pathology, Penn State College of Medicine; Co-director, Bioinformatics and Genomics Option, IBIOS Intercollege Graduate Program 


Genetics, Pathology, Cancer, Zebrafish, Web-based scientific resources, Genomic Instability, Histopathology, Skin Pigmentation, Systems Genetics, Image Recognition in Biology 


Lamason RL, Mohideen M-AP, Mest JR, Wong AC, Norton HL, Aros MC, Juurynec MJ, Mao X, Humphreville VR, Humbert JE, Sinha S, Moore JL, Jagadeeswaran P, Ning G, Makalowska I, Zhao W, McKeigue PM, O'Donnell D, Kittles R, Parra EJ, Mangini NJ, Grunwald DJ, Shriver MD, Canfield VA, Cheng KC. SLC24A5 affects pigmentation in zebrafish and man. Science 310:1782-1786, 2005. (cover article) PMID: 16357253
Zinnanti WJ, Lazovic J, Wolpert EB, Antonetti DA, Smith MB, Connor JR, Woontner M, Goodman SI, Cheng KC. A diet-induced mouse model for glutaric aciduria type I. Brain 129:899-910, 2006. PMID: 16446282
Cheng KC. The golden mutation in zebrafish. Commentary #1, February 2006 PASPCR web-site posting.
Cheng KC. Bach's Goldberg Variations: An artistic inspiration for art, science, medicine, and life. Wild Onions 20:14-15, 2006.
Blasiole B, Canfield VA, Mohideen M-APK, Vollrath MA, Huss D, Dickman JD, Cheng KC, Fekete DM, Levenson, RL. Separate Na,K-Atpase genes are required for otolith formation and semicircular canal development in zebrafish. Dev Biol 294:148-160, 2006. PMID: 16566913
Zinnanti WJ, Lazovic J, Wolpert EB, Antonetti DA, Smith MB, Connor JR, Woontner M, Goodman SI, Cheng KC. New insights for glutaric aciduria type I. Brain 129:E55, 2006. PMID: 16870880
Sabaliauskas NA, Foutz CA, Mest JR, Budgeon LR, Sidor A, Gershenson J, Joshi S, Cheng KC. High-throughput zebrafish histology. Methods 39:246-254, 2006. PMID: 16870470
Moore JL, Rush LM, Breneman C, Mohideen M-AP, Cheng, KC. Zebrafish genomic instability mutants and cancer susceptibility. Genetics 174:585-600, 2006 (October cover article), 2006. PMID: 16888336
Cheng KC, Canfield VA. The role of SLC24A5 in skin color. Invest Dermatol 16:836-838, 2006.
Chi A, Valencia JC, Hu Z-Z, Watabe H, Yamaguchi H, Mangini NM, Huang H, Canfield VA, Cheng KC, Yang OF, Abe R, Yamagishi S, Shabanowitz J, Hearing VJ, Wu C, Appella E, Hunt DF. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. J Proteome Res 5:3135-3144, 2006. PMID: 17081065
Norton HL, Kittles RA, Parra E, McKeigue P, Mao X, Cheng KC, Canfield VA, Bradley DG, McEvoy B, Shriver MD. Genetic evidence for the convergent evolution of light skin in Europeans and East Asians. Molecular Biol Evol 24:710-722, 2007. PMID: 17182896
Zinnanti WJ, Lazovic J, Housman C, LaNoue K, O'Callaghan JP, Simpson I, Woontner M, Goodman SI, Connor JR, Jacobs RE, Cheng KC. Mechanism of age-dependent susceptibility and novel treatment strategy in glutaric acidemia type I. J Clin Invest 117:3258-3270, 2007. PMID: 17932566
Canada BA, Thomas GK, Cheng KC*, Wang JZ.* Automated segmentation and classification of zebrafish histology images for high-throughput phenotyping. Proceedings of the Third IEEE-NIH Life Science Systems and Applications Workshop, pp. 245-248, Washington, D.C., November 2007. (*equal contributors) ISBN number: 978-1-4244-1813-8