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David Malehorn

PROJECT AFFILIATION:

PROFESSIONAL ROLES

  • Higher Ed: Science 

BIO

Eastern Illinois University, Charleston IL [1980-82] Environmental Biology
University of Illinois, Urbana-Champaign IL [82-84] BS in Microbiology
University of Illinois, Urbana-Champaign IL [84-86] MS in Microbiology
University of Illinois, Urbana-Champaign IL [86-89] PhD in Microbiology
Monsanto Agricultural Company, St. Louis MO [90-93] Post Doctoral research in Plant Molecular Biology

1993"2000 Director of Molecular Biology, Midland Certified Reagent Co, Midland TX

2001-2002 Director of Product Development, Sequel Genetics Inc, Pittsburgh PA

2002-2003 Technical Support and Training Manager, Eurogentec NA Inc, Philadelphia PA

2003" Research Assistant Professor, University of Pittsburgh School of Medicine, Dept of Pathology 

EXPERTISE

Trained in molecular biology in three different model systems (retrovirus, yeast, plants)

Professionally employed as an industrial genetic engineer for ten years.

Presently working in Clinical Proteomics toward biomarker discovery for better early detection of disease 

RECENT PUBLICATIONS

Hauskrecht M, Pelikan R, Malehorn D, Bigbee WL, Lotze MT, Zeh HJ, III, Whitcomb DC, Lyons-Weiler J. Feature selection for classification of SELDI-TOF-MS proteomic profiles. Appl Bioinformatics 2005;4:227-46.

Lyons-Weiler J, Pelikan R, Hauskrecht M, Malehorn D, Bigbee WL. Assessing the statistical significance of the achieved classification error of classifiers constructed using serum peptide profiles, and a prescription for random sampling repeated studies for massive high-throughput genomic and proteomic studies. Cancer Informatics 2005;1:53-77.

Miyamae T, Malehorn DE, Lemster B, Mori M, Imagawa T, Yokota S, Bigbee WL, Welsh MJ, Klarskov K, Nishomoto N, Vallejo AN, Hirsch R. Serum protein profile in systemic-onset juvenile idiopathic arthritis differentiates response versus non-response to therapy. Arthritis Res Ther 2005;7: R746-R755.

Jahnukainen T, Malehorn D, Sun M, Lyons-Weiler J, Bigbee W, Gupta G, Shapiro R, Randhawa PS, Pelikan R, Hauskrecht M, Vats A. Proteomic analysis of urine in kidney transplant patients with BK virus nephropathy. J Am Soc Nephrol 2006;17:3248-56.

Papachristou GI, Malehorn DE, Lamb J, Slivka A, Bigbee WL, Whitcomb DC. Serum proteomic patterns as a predictor of severity in acute pancreatitis. Pancreatology 2007;7:317-324.

Pelikan R, Bigbee WL, Malehorn D, Lyons-Weiler J, Hauskrecht M. Intersession reproducibility of mass spectrometry profiles and its effect on accuracy of multivariate classification models. Bioinformatics 2007 (in press).

Telmer CA, An J, Malehorn DE, Zeng X, Gollin SM, Ishwad CS, Jarvik JW. Detection and assignment of TP53 mutations in tumor DNA using peptide mass signature genotyping. Hum Mutat. 2003 Aug;22(2):158-65.

Malehorn DE, Telmer CA, McEwen SB, An J, Kinsey AD, Retchless AC, Mason C, Vieta WM, Jarvik JW. Detection of cystic fibrosis mutations by peptide mass signature genotyping. Clin Chem. 2003 Aug;49(8):1318-30.