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Jason Labonte

PROJECT AFFILIATION:

PROFESSIONAL ROLES

  • Higher Ed: Science, Higher Ed: Engineering, Researcher 

BIO

EXPERTISE

RECENT PUBLICATIONS

Labonte, J.W.; Townsend, C.A. "Active site comparisons and catalytic mechanisms of the hot dog superfamily," Chem. Rev., Article ASAP.


Vagstad, A.L.; Hill, E.A.; Labonte, J.W.; Townsend, C.A. "Characterization of a fungal thioesterase having Claisen cyclase and deacetylase activities in melanin biosynthesis," Chem. Biol. 2012, 19, 1525-1534.

Buller, A.R.; Labonte, J.W.; Freeman, M.F.; Wright, N.T.; Schildbach, J.F.; Townsend, C.A. "Autoproteolytic activation of ThnT results in structural reorganization necessary for substrate binding and catalysis," J. Mol. Biol. 2012, 422, 508-518.

Labonte, J.W.; Kudo, F.; Freeman, M.F.; Raber, M.L.; Townsend, C.A. "Exploring the synthetic potential of engineered -lactam synthetase and the importance of catalytic loop dynamics," Med. Chem. Commun. 2012, 3, 960-966.

Korman, T.P.; Crawford, J.M.; Labonte, J.W.; Newman, A.G.; Wong, J.; Townsend, C.A.; Tsai, S.-C. "Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in Aflatoxin biosynthesis," Proc. Natl. Acad. Sci. 2010, 107, 6246-6251.

Crawford, J.M.; Korman, T.P.; Labonte, J.W.; Vagstad, A.L.; Hill, E.A.; Kamari-Bidkorpeh, O.; Tsai, S.-C.; Townsend, C.A. "Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization," Nature 2009, 461, 1139-1143.