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Member Profile


Doug Evans

PROJECT AFFILIATION:

PROFESSIONAL ROLES

BIO

EDUCATION
1978-1983 B.S., cum laude,
Physiology & Anatomy
University of Utah
Salt Lake City, Utah
Taught Biology 101, Introduction to Biology, and examined the effect of different wavelengths and porphyrins on the generation of reactive oxygen species.

1983-1990 Ph.D.
Biomedical Science & Cancer Biology
Department of Tumor Biology
University of Texas Graduate School of Biomedical Sciences
Houston, Texas
Examined the effects of hyperthermia on mammalian-cell killing, heat stress protein synthesis, and the development of thermotolerance. Special emphasis placed on calmodulin and other calcium-binding proteins.


EMPLOYMENT
7/12/2004 - present
Los Angeles Unified School District
Francisco Bravo Medical Magnet - Science Department
Taught Biology, Chemistry, AP Biology, and Physiology to students in 9th-12th grade.

2000 - 2003
Postdoctoral Fellow
Cedars-Sinai Prostate Cancer Center
Los Angeles, California
Examined the relationship between members of the HER-kinase axis (EGFR, HER2, HER3, etc.) and prostate cancer using in vitro, in vivo, mRNA and protein analyses. Established human xenografts and in vitro cell strains while examining the potential mechanisms for paclitaxel (Taxol) and docetaxel (Taxotere) resistance.

1999 - 2000
Postdoctoral Fellow
Department of Pathology and Laboratory Medicine
University of California Los Angeles
Los Angeles, California
Examined the relationship between CD-45 and galectin-1 induced T cell death (apoptosis).

1999 (part time)
Freelance Medical Writer
Zynx Corporation
Beverly Hills, California
Wrote brief summaries of current literature for an on-line library that was available for Cedars-Sinai physicians.


1998 - 1999
Medical Writer/Publications Coordinator
California Clinical Trials
Beverly Hills, California
Prepared presentations, slides, posters, abstracts, and wrote one review on the recent developments in Alzheimer's disease.

1997 - 1998 (part time)
Adjunct Professor
Department of Mathematics and Natural Sciences
National University
Los Angeles, California
Taught ecology and plant biology to non-traditional students, i.e., middle-aged, in the work force, and returning to higher education in order to advance in the workplace.

1994 - 1996
Postdoctoral Fellow
Dept of Medicine and Dept of Pediatrics
Maternal and Child HIV / ACTG, WIHS clinical trials
School of Medicine
University of Southern California
Los Angeles, California
Managed the regional (Los Angeles) laboratory for the Women's Interagency HIV study clinical trials (WIHS) and AIDS Clinical Trials Group (ACTG). Our studies examined the use of AZT on HIV transmission from mother to child. I managed six MD and /or PhD co-workers as well as research assistants, interns, and volunteers. Our group was responsible for the collection, separation, preparation of body fluids (blood, saliva, gynecological, etc.), and shipment of these biohazardous materials for assays done elsewhere.

1990 - 1994
Postdoctoral Fellow
Departments of Pathology, and Molecular Pharmacology and Toxicology
School of Medicine
University of Southern California
Los Angeles, California
Studied metal- and tobacco-induced gene expression and neoplastic transformation of cells in vitro. Examined the effect of cyclooxygenase and lipooxygenase inhibitors on the induction of transformation by nickel-, arsenic-, and chromium-compounds. 

EXPERTISE

RECENT PUBLICATIONS

PUBLICATIONS

1. Agus DB, Akita RW, Fox WD, Lewis GD, Higgins B, Pisacane PI, Lofgren JA, Tindell C, Evans DP, Maiese K, Scher HI, and Sliwkowski MX, 2002, Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth. Cell Cancer 2:127-137.
2. Nguyen JT, Evans DP, Galvan M, Pace KE, Leitenberg D, Bui TN, and Baum LG., 2001, CD-45 modulates galectin-1 induced T cell death: regulation by expression of core 2 O-glycans, J Immunol 167:5697-5707.
3. Sramek JJ and Cutler NR, 1999, Recent developments in the drug treatment of Alzheimer's disease. Drugs Aging 14:359-373 (Evans DP - Ghostwriter for this review).
4. Evans DP, Corbin JR, and Tomasovic SP, 1991, Effects of calcium buffering on the synthesis of the 26-kDa heat stress protein family, Radiat Res 127:261-268.
5. Evans DP and Tomasovic SP, 1990, Affinity isolation of heat-shock and other calmodulin-binding proteins following hyperthermia, Radiat Res 124:50-56.
6. Evans DP, Simonette RA, Rasmussen CD, Means AR, and Tomasovic SP, 1990, Altered synthesis of the 26-kDa heat stress protein family and thermotolerance in cell lines with elevated levels of calcium-binding proteins, J Cell Physiol 142:615-627.
7. Evans DP and Tomasovic SP, 1989, The effect of calmodulin antagonists on hyperthermic cell killing and the development of thermotolerance, Int J Hyperthermia 5:563-578.
8. Evans DP, Meyn RE, and Tomasovic SP, 1986, Survival of rat mammary tumor cell clones and DNA strand damage following Adriamycin treatment, Cancer Chemother Pharmacol 18:137-139.
9. Welch DR, Evans DP, Tomasovic SP, Milas L, and Nicolson G, 1984, Multiple phenotypic divergence of mammary adenocarcinoma cell clones. II. Sensitivity to radiation, hyperthermia and FUDR, Clin Exp Metastasis 2:357-371.

BOOK CHAPTERS AND REVIEWS
1. Landolph JR, Dews PM, Osburn L, and Evans DP, 1996, Metal-induced gene expression and neoplastic transformation. In: Toxicology of Metals, edited by LW Chang (London: CRC Lewis Publishers), pp 321-329.
2. Welch DR, Evans D, Tomasovic S, Krizman D, Milas L, and Nicolson G, 1984, Multiple phenotypic divergence of mammary adenocarcinoma cell clones. In: Treatment of Metastasis: Problems and Prospects, edited by K Hellman and S Eccles (London: Taylor and Francis, Ltd), pp 239-242.

ABSTRACTS
1. A Jain, C Tindell, DP Evans, L Mullen, H Scher, K Gish, D Afar, A Kennon-Frink, and DB Agus. Potential mechanism for paclitaxel resistance in prostate cancers. Keystone Conference, Banff, Canada; 2003.
2. CA Tindell, A Jain, DP Evans, L Mullen, HI Scher, K Gish, D Afar, and DB Agus. Potential mechanism for taxol resistance in prostate cancer. 94th Annual Meeting of the American Association for Cancer Research, Toronto, Ontario, Canada; (rescheduled for Washington D.C.), 2003.
3. DP Evans, LM Mullen, CA Tindell, VA Patel, and DB Agus. Differential prostate tumor RNA and protein expression in the HER kinase axis: In vitro versus in vivo. 93rd Annual Meeting of the American Association for Cancer Research, San Francisco, CA; 2002.
4. WD Fox, CA Tindell, A Galkin, J Geller, DP Evans, and DB Agus. Anti-tumor effects of 2C4, a humanized monoclonal antibody targeted to an epitope of the Her-2/neu extracellular domain, in human prostate cancer xenografts. WAACR-NCI-EORTC International Conference, Miami Beach, FL; 2001.
5. JR Landolph, D Evans, A Tasci, J Weng, and M Dews. Transformation of mammalian cells by tobacco carcinogens. First Tobacco-Related Disease Research Program Scientific Conference; Los Angeles, CA; 1993.
6. JR Landolph, M Dews, D Evans, and RA Biedermann. Molecular mechanisms of transformation of 10T1/2 mouse embryo cells and diploid human fibroblasts by carcinogenic arsenic, nickel, and chromium compounds. 2nd International Meeting on Molecular Mechanisms of Metal Toxicity and Carcinogenicity; Italy; 1993.
7. T Sakuramoto, D Evans, T Miura, M Meskin, J Nwankwo, and JR Landolph. Oncogene expression in nickel transformed C3H/10T1/2 cell lines. 82nd Annual Meeting of the American Association for Cancer Research; Houston, TX; 1991.
8. SP Tomasovic, JR Corbin, CD Rasmussen, AR Means and DP Evans. Overproduction of protein kinase C or calmodulin modulates the rates of synthesis of the mammalian 26-kDa heat stress proteins. 11th Annual Meeting of the European Society of Hyperthermic Oncology; Ravello, Italy; 1990.
9. DP Evans, R Corbin and SP Tomasovic. Effects of Ca2+-buffers on synthesis of the 26 kDa heat stress proteins. 38th Annual Meeting of the Radiation Research Society; New Orleans, LA; 1990.
10. DP Evans, RA Simonette, CD Rasmussen, AR Means, and SP Tomasovic. Heat sensitivity and thermotolerance development in cell lines overexpressing Ca2+-binding proteins. 29th Annual Meeting of the American Society for Cell Biology; Houston, TX; 1989.
11. DP Evans, RA Simonette, CD Rasmussen, AR Means, and SP Tomasovic. Altered synthesis of low molecular weight heat stress proteins in cell lines overexpressing Ca2+-binding proteins. 37th Annual Meeting of the Radiation Research Society; Seattle, WA; 1989.
12. SP Tomasovic and DP Evans. Calmodulin antagonists, the heat stress protein response and thermotolerance. 1988 UCLA Symposia in Molecular and Cellular Biology; Keystone, CO; 1988.
13. DP Evans and SP Tomasovic. Calmodulin-regulated processes in heat killing and thermotolerance. 36th Annual Meeting of the Radiation Research Society; Philadelphia, PA; 1988.
14. DP Evans and SP Tomasovic. Temperature-dependent potentiation of hyperthermic cell killing by a calmodulin antagonist. 63rd Annual Meeting of the American Association for the Advancement of Science; Austin, TX; 1987.
15. DP Evans and SP Tomasovic. Effect of a calmodulin antagonist on hyperthermic cell killing and the development of thermotolerance. 35th Annual Meeting of the Radiation Research Society; Atlanta, GA; 1987.
16. DP Evans, SP Tomasovic, and TV Updyke. Reduced affinity isolation of calmodulin binding proteins following cellular heat stress. 33rd Annual Meeting of the Radiation Research Society; Los Angeles, CA; 1985.
17. DR Welch, DP Evans, SP Tomasovic, D Krizman, L Milas, and GL Nicolson. Simultaneous and independent drift of multiple phenotypes in mammary adenocarcinoma cell clones. Treatment of Metastasis: Problems and Prospects: London, UK; 1984.