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Corey Nislow



  • Higher Ed: Science 


I am an Assistant Professor in the Banting and Best Department of Medical Research and have a status-only co-appointment in Department of Medical Genetics and Microbiology. I joined the University of Toronto in May 2006, coming from the Stanford Genome Technology Center . At Stanford, I co-directed the chemical genomics laboratory with my wife, and better half, Dr. Guri Giaever. Together, with the help of Bob St. Onge our Stanford Project Manager, we developed many of the assays described here. We have been fortunate to have secured several years of continuous grant support from the National Human Genome Research Institute within the NIH, and from the Canadian Institute for Health Research. My current interests include; 1) using model organisms to understand the mechanism of action of human therapeutics, 2) using high-throughput cell biology to investigate drug synergy, and 3) developing technologies for understanding the relationship between chromatin structure and transcriptional regulation. We are a collaborative group and have been lucky to work with many fantastic labs. 


Functional genomics
chemical biology
next generation sequencing


Ho CH, Magtanong L, Baker SL, Gresham D, Nishimura S, Natarajan P, Koh JL, Porter J, Gray CA, Anderson RJ, Giaever G, Nislow C, Andrews B, Botstein D, Graham TR, Yoshida M, Boone C. A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds.Nat Biotechnol. 2009 Apr 14. 27(4):369-77.Epub 2009 Apr 6.

Yan Z, Berbenetz NM, Giaever G, Nislow C. Precise gene dose alleles for chemical genetics.Genetics. 2009 Mar 30. [Epub ahead of print]

Jo WJ, Kim JH, Oh E, Jaramillo D, Holman P, Loguinov AV, Arkin AP, Nislow C, Giaever G, Vulpe CD. Novel insights into iron metabolism by integrating deletome and transcriptome analysis in an iron deficiency model of the yeast Saccharomyces cerevisiae.BMC Genomics. 2009 Mar 25;10:130.

Hess DC, Myers CL, Huttrnhower C, Hibbs MA, Hayes AP, Paw J, Clore JJ, Mendoza RM, Luis BS, Nislow C, Giaever G, Costanzo M, Troyanskaya OG, Caudy AA. Computationally driven quantitative experiments discover genes required for mitochondrial biogenesis.PLoS Genet. 2009 Mar;5(3):e1000407. Epub 2009 Mar 20.

Giaever G, Nislow C. Knocking sense into regulatory pathways.Nat Biotechnol. 2009 Feb. 27(2):149-50. No abstract available

Kemmer D, McHardy LM, Hoon S, Rebrioux D, Giaever G, Nislow C, Roskelley CD, Roberge Michel. Combining chemical genomics screens in yeast to reveal spectrum of effects of chemical inhibition of sphingolipid biosynthesis.BMC Microbiology. 2009 Jan 14.

Badis G, Chan ET, van Bakel H, Pena-Castillo L, Tillo D, Tsui K, Carlson CD, Gossett AJ, Hasinoff MJ, Warren CL, Gebbia M, Talukder S, Yang A, Mnaimneh S, Terterov D, Coburn D, Li Yeo A, Yeo ZX, Clarke ND, Lieb JD, Ansari AZ, NIslow c, Hughes TR. A library of yeast transcription factor motifs reveals a widespread function for Rsc3 targeting nucleosome exclusion at promoters.Mol Cel. 2008 Dec 26;32(6):878-87.

Yu L, Lopez A, Anaflous A, El Bali B, Hamal A, Ericson E, Heisler LE, McQuibban A, Giaever G, Nislow C, Boone C, Brown GW, Bellaoui M. Chemical-genetic profiling of imidazo[1,2-a]pyridines and -pyrimidines reveals target pathways conserved between yeast and human cells.PLoS Genet. 2008 Nov;4(11):e1000284. Epub 2008 Nov 28

Lehr J, Stockwell BR, Giaever G, Nislow C. Combination chemical genetics. Nat Chem Biol. 2008 Nov;4(11):674-681. Epub 2008 Oct 20.

Hoon S, St Onge RP, Giaever G, Nislow C. Yeast chemical genomics and drug discovery: an update. Trends Pharmacol Sci. 2008 Aug 26. [Epub ahead of print]

Ericson E, Gebbia M, Heisler LE, Wildenhain J, Tyers M, Giaever G, Nislow C. Off-target effects of psychoactive drugs revealed by genome-wide assays in yeast. PLoS Genet. 2008 Aug 8;4(8):e1000151.

Yan Z, Costanzo M, Heisler LE, Paw J, Kaper F, Andrews BJ, Boone C, Giaever G, Nislow C. Yeast Barcoders: a chemogenomic application of a universal donor-strain collection carrying bar-code identifiers. Nat Methods. 2008 Aug;5(8):719-25. Epub 2008 Jul 11.

Hoon S, Smith AM, Wallace IM, Suresh S, Miranda M, Fung E, Proctor M, Shokat KM, Zhang C, Davis RW, Giaever G, St. Onge RP, Nislow C. An integrated platform of genomic assays reveals small-molecule bioactivities. Nat Chem Biol. 2008 Aug;4(8):498-506. Epub 2008 Jul 11.