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Scott Holmes



  • Higher Ed: Science 


B.S. William and Mary (Biology)
Ph.D. University of Virginia (Microbiology)
Post-doc Princeton University (Broach Lab)

Faculty in the Molecular Biology and Biochemistry Department at Wesleyan University since 1997

At Wesleyan my recent teaching responsibilities have been our sophomore-level Molecular Biology course, and Advanced Laboratory in Molecular Biology and Genetics. I have also taught graduate level courses in Epigenetics and Gene Expression, and non-majors courses that cover focused topics in genetics.

In fall 2009 I will teach our introductory biology course for the first time.

I also run a research lab that currently includes three PhD students and three undergraduates, where we study the role of chromosome structure on gene expression. We are specifically interested in determining the mechanism of silencing in budding yeast, a form of gene repression that controls the expression of key genes that dictate cell fate in yeast. 


Molecular biology and genetics of chromosome structure and gene expression. 


Hickman, M., K. McCullough, A. Woike, L. Raducha-Grace, T. Rozario, M. L. Dula, E. Anderson, D. Margalit, and S. G. Holmes, 2007. Isolation and characterization of conditional alleles of the yeast SIR2 gene. Journal of Molecular Biology 367:1246-1257.

Matecic, M., K. Martins-Taylor, M. Hickman, J. Tanny, D. Moazed, and S. G. Holmes, 2006. New alleles of SIR2 define cell cycle specific silencing functions. Genetics 173:1939-1950.

Martins-Taylor, K., M.L. Dula, and S.G. Holmes, 2004. Heterochromatin spreading at yeast telomeres occurs in M-phase. Genetics 168: 65-75.